Pre-Clinical group and Da-Ta Biotech (In-vitro models) are collaborating expert Israeli CRO companies in the field of Cancer drug development. We have the capability to setup any required specific model.
Available models for in vivo cancer research
Allograft models – the inoculation of cells (dispersed, organs, tissues) from one to another individual (source) from the same species. For cancer research the mostly used models are Mice and rats.
Xenograft models – the inoculation of cells (dispersed, organs, tissues) from one individual (source) to another from a different species. This usually involves the use of models with an impaired immune system for avoiding rejection.
Matrix formation - Cells can be inoculated with or without matrix that helps to confined them so that 100% of the inoculated individuals are included and a single tumor mass is formed.
Hollow fibers – The first line screening model of the National Cancer Institute (NCI) – for screening the 60 cell lines battery for evaluating a new anti cancer drug and it's potential. That model is exclusively performed by Da-Ta Biotech and Pre-Clinical group in Israel. The model enables the in vivo evaluation of treatment efficacy towards cell lines that are reluctant from growing in a mouse model. To learn more about Hollow Fiber model
Cancer models available Lung, breast, liver, colon and ovary cancers, hematological cancer and melanoma.
Inoculation sites Subcutaneous, intra peritoneal Orthotopic inoculation, and Metastatic
Treatment options Subcutaneous, Intra Peritoneal, Intra Venous, Intra Muscular, Slow infusion, and Intra tumoral
Tumor Measured Parameters
Tumor size by caliper, Organ mass and metastases density and size
